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2-Methyl-3-butyn-2-ol 2-甲基-3-丁炔-2-醇

规格: 98%

CAS: 115-19-5

产品编号: H91470

MDL: MFCD00004467

品牌: INFI

Chemical Name	2-Methyl-3-butyn-2-ol
CAS Number	115-19-5
Alfabeta Name	METHYLBUTYNOL 232-----
MDL Number	MFCD00004467
Synonym	1,1-Dimethyl-2-propyn-1-ol 1,1-dimethylpropargylalcohol 1,1-dimethylpropynol 2-Hydroxy-2-methyl-3-butin 2-Methyl-3-butyne-2-ol 2-Methylbut-3-in-2-ol 2-methylbut-3-yn-2-ol 2-甲基-3-丁炔-2-醇 3-Butyn-2-ol, 2-methyl- 3-METHYL-1-BUTYN-3-OL 3-Methyl-1-butyn-3-ol 3-Methyl-3-hydroxy-1-butyne 3-Methyl-butin-(1)-ol-(3) 3-Methylbut-1-yn-3-ol 3-羥-3-甲-1-丁炔 AB 32 (alcohol) Dimethyl ethynyl carbinol,2,2-Dimethylpropargyl alcohol Dimethyl ethynyl carbinol; 2,2-Dimethylpropargyl alcohol Dimethylethynylmethanol Ethinyl-dimethylca Ethynyldimethylcarbinol alpha,alpha-Dimethylpropargyl alcohol {} {} {} {} {C {} {} {} {} {Chemicalbook} {} {} {} {} {uni_hambur α,α-Dimethylpropargyl alcohol
EC Number	204-070-5
Beilstein Registry Number	635746
PubChem Substance ID	8258
Reaxys-RN	635746
Merck Number	6034
Chemical Name Translation	2-甲基-3-丁炔-2-醇
Wiswesser Line Notation	QX1&1&1UU1
LabNetwork Molecule ID	LN00175014
InChI	InChI=1S/C5H8O/c1-4-5(2,3)6/h1,6H,2-3H3

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(4),55,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1161 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 76,181,1956

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/m3
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(4),55,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than

Warnings	危化品目录(2015) IRRITANT
WGK Germany	1
Hazard Codes	3
Hazard statements
H226 Flammable liquid and vapour 易燃液体和蒸气 H351 Suspected of causing cancer 怀疑致癌 H318 Causes serious eye damage 严重伤害眼睛 H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H302 Harmful if swallowed 吞食有害 H317 May cause an allergic skin reaction 可能导致皮肤过敏
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P312+P330 P303+P361+P353 P304+ P305+P351+P338 P370+P378 P403+P235 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Danger
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Safety Statements
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护； S39 Wear eye/face protection 戴眼睛/面孔保护装置； S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
R10 Flammable 易燃 R22 Harmful if swallowed 吞咽有害 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
RTECS	ES0810000
UN Number	1987
Packing Group	II
Hazard Class	3
Storage condition	Flammables area
Restrict	危险品

{ALF} Alternatively, the protecting group can be removed from the intermediate by base to give monoarylacetylenes: J. Org. Chem., 48, 5135 (1983); 57, 6998 (1992). For an improved procedure, see: Synthesis, 589 (1996).

{ALF} Adduct of acetylene and acetone which acts as an acetylene equivalent in the Pd-catalyzed (Sonogashira) coupling reaction with aryl or heteroaryl halides, permitting a one-pot diarylation by different halides: Synthesis, 571 (1984):

{uni_hamburg} Short: III/38B

{ALD} Merck:14,6034

{uni_hamburg} Short: IV/18B

{ALD} Merck:14,6034

Beilstein:1(1)235

115-19-5 H91470 2-Methyl-3-butyn-2-ol
2-甲基-3-丁炔-2-醇

化学属性

Mol. Formula	C5H8O
Mol. Weight	84
Density	0.848
Refractive index	1.4200 to 1.4230
Boiling Point	104 °C(lit.)
Melting Point	0 - 6 °C (lit.)
Flash Point	68 °F
TSCA	Yes
Autoignition Point	662 °F
Vapor Pressure	15 mmHg ( 20 °C)
Solubility	与水混溶，可混溶于丙酮、苯、四氯化碳、石油醚。
Danger-Level	甲类

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

2-Methyl-3-butyn-2-ol 2-甲基-3-丁炔-2-醇

规格: 98%

化学属性

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