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4’-Hydroxyacetophenone 4-羟基苯乙酮

规格: 98%
CAS: 99-93-4
产品编号: H87234
MDL: MFCD00099934
品牌: INFI
Chemical Name4’-Hydroxyacetophenone
MDL NumberMFCD00002359
CAS Number99-93-4
Beilstein Registry Number8,87
PubChem Substance ID87570625
EC Number202-802-8
Synonym p-Hydroxyacetophenone 4'-Hydroxyacetophenone USAF KF-15
Chemical Name Translation4-羟基苯乙酮
Reaxys-RN774355
Wiswesser Line NotationQR DV1
LabNetwork Molecule IDLN00193778
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEXPAG Medicina Experimentalis.  (Basel, Switzerland)  V.1-11, 1959-64;
   V.18-19, 1968-69.  For publisher information, see JNMDBO.
   Volume(issue)/page/year: 11,137,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 41,43,1990

WGK Germany3
Signal word
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H319 Causes serious eye irritation 严重刺激眼睛
    Hazard Codes Xn
    RTECSAM8750000
    Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
    Safety Statements
    • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
    • S22 Do not breathe dust 不要吸入粉尘;
    • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
    • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
      Risk Statements
      • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      • R22 Harmful if swallowed 吞咽有害
        Storage condition 充氩保存
        Precautionary statements
        • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
        • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
        • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
        • P501 Dispose of contents/container to..… 处理内容物/容器.....
        • P332+P313
        • P302+P352+P332+P313+P362+P364
        • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
        • P305+P351+P338+P337+P313
        • P301+P312+P330
        • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
        • P305+P351+P338
        • 作为有机合成的中间体,可用于香料的生产,对羟基苯乙酮还是一种利胆的药品,适用于胆囊炎和急、慢性黄胆型肝炎的辅助治疗。主要是用莱合成a-溴代对羟基苯乙酮是合成选择性B l受体阻滞剂一阿替洛尔(#1)的重要中间体。
        • {SA}
        • Beil. 8 ,87
        • {SA}
        • Aldrich MSDS 1 , 1051:B / Corp MSDS 1 (1), 1902:A / FT-IR 1 (2), 44:B / FT-NMR 1 (2), 861:B / NMR-Reference 2 (2), 34:C / RegBook 1 (2), 1651:B / Sax 6 , 1556 / Sigma FT-IR 1 (2), 619:A / Structure Index 1 , 260:C:4 / Vapor Phase 3 , 1259:A
        • 99-93-4 H87234 4’-Hydroxyacetophenone	4-羟基苯乙酮

          化学属性

          Mol. FormulaC8H8O2
          Mol. Weight136.15
          Boiling Point148°C/3mmHg(lit.)
          Melting Point109.0 to 112.0 deg-C
          Flash Point166°(330°F)
          TSCAYes
          Density1.109
          SolubilitySoluble in 95% Ethanol.
          Stability易吸潮

          *以上化合物性质及应用等信息仅供参考