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2-Bromo-4'-methoxyacetophenone 2-溴-4'-甲氧基苯乙酮

规格: 98%

CAS: 2632-13-5

产品编号: H86803

MDL: MFCD00000201

品牌: INFI

Chemical Name	2-Bromo-4’-methoxyacetophenone
CAS Number	2632-13-5
Synonym	PTP inhibitor 1 {LY} PTP inhibitor 1 {} {LY} PTP inhibitor 1 {} {} {LY} PTP inhibitor 1 {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP in
MDL Number	MFCD00000201
EC Number	220-118-8
Beilstein Registry Number	743112
PubChem Substance ID	87572980
Reaxys-RN	743112
Chemical Name Translation	alpha-溴-4-甲氧基苯乙酮
InChIKey	XQJAHBHCLXUGEP-UHFFFAOYSA-N
LabNetwork Molecule ID	LN00220084
Canonical SMILES	COC1=CC=C(C(CBr)=O)C=C1

GHS Symbol

Signal word	Danger
WGK Germany	3
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服； S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
R34 Causes burns 会导致灼伤 R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P330+P331+P310 P303+P361+P353 P304+P340+P310 P305+P351+P338 P305+P351+P338+P310 P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
H290 May be corrosive to metals 可能腐蚀金属。 H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤 H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing Group	II
UN Number	3261
Hazard Codes	8 C
Hazard Class	8
Storage condition	2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

2-Bromo-4'-methoxyacetophenone is a ?-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.

{ALD} Beilstein:8(4)351

{TRC} Elchelby, M., et al.: Science, 283, 1544 (1999),

{ALF} Reagent for protection of carboxylic acids as 4-methoxyphenacyl esters, which may be prepared in the presence of KF as base: Synthesis, 897 (1981) and can be cleaved photolytically: J. Org. Chem., 38, 3771 (1973). Peptide bonds are generally unaffected by irradiation but some cleavage of trityl protecting groups may occur. See also Appendix 6. For further discussion of this and other photo-removable protecting groups, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987).

{TRC} Shen, K., et al.: J. Biol. Chem., 276, 47311 (2001),

{TRC} Taylor, W., et al.: Bioorg. Med. Chem., 4, 1515 (1996),

{MCE} [1]. Sylvest L, et al. Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS. 2010 Jan;118(1):49-59.

2632-13-5 H86803 2-Bromo-4'-methoxyacetophenone
2-溴-4'-甲氧基苯乙酮

化学属性

Mol. Formula	C9H9BrO2
Mol. Weight	229.07
Density	1.448
Melting Point	69-72°C
TSCA	No
Boiling Point	306.7°C at 760 mmHg

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

2-Bromo-4'-methoxyacetophenone 2-溴-4'-甲氧基苯乙酮

规格: 98%

化学属性

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